Li-Resin-amine (or, amino-li-resin)

For Li-Resin, professor Fernando Albericio and his team systematically studied its characteristic properties and found it appropriate for solid phase peptide synthesis. The excellent performance of the resin has been demonstrated for the synthesis of several model peptides including difficult sequences and those containing hindered amino acids[1]. A practical peptide synthesis workflow has also been established for its use[2]. More significantly, Li-Resin has proven to be a suitable support for peptide synthesis in aqueous system using SulfoTools’ SMOC protecting strategy. Its optimal swelling property and robust chemical stability are most favorable factors for industrial applications[3]. This type of resin had been developed previously and applied successfully for practical solid phase synthesis of oligonucleotide[4].

References:

[1] Damilola C. Akintayo, Beatriz G. de la Torre, Yongfu Li and Fernando Albericio: Polymers 2022, 14(5), 28 https://doi.org/10.3390/polym14050928.

[2] Damilola C. Akintayo, Srinivasa R. Manne, Beatriz G. de la Torre, Yongfu Li and Fernando Albericio: Methods and Protocols 2022, 5(5), 72 https://doi.org/10.3390/mps5050072.

[3] Christina Uth, Simon Englert, Olga Avrutina, Harald Kolmar and Sascha Knauer: Journal of Peptide Science 2023, 29(12), e3527. https://doi.org/10.1002/psc.3527.

[4] E. Atherton, M. J. Gait, R. C. Sheppard and B. J. Williams: Bioorganic Chemistry 1979, 8, 351-370 and references therein (a) Nucleic Acids Research 1977, 4, 1135-1158 (b) Nucleic Acids Research 1977, 4, 4391-4410.